PARKINSON’S DISEASE, CAUSE, PROGRESSION AND TREATMENT

Amit kumar, Shivani Dogra, Hem Raj Vashist, RB Sharma

Abstract


Parkinson is a neurdegerated diseasethat affects as many as 1-2% person Alpha-synuclein play significant pathogenic role in this disease. Therapeutic advances based on a syneulein related mechanism are now developed. Current therapy is mainly based on a dopamine replacement strategy using the precursor levodopa and dopamine receptor agonist. The urrent only provide symptomatic relief and fail to halt the death of dopaminergic neurons.The present study is to compile and study different aspects of parkinsonism.


Keywords


Parkinson, Alpha-synuclein, Dopamine

Full Text:

1-6

References


Sherer TB, S Chowdhury, K Peabody, D Brooks: Overcoming obstacles in Parkinson's disease. Movement Disorders 27(13), 1606-1611 (2012)

http://dx.doi.org/10.1002/mds.25260 PMid:23115047

Chou K: Clinical manifestations of Parkinson Disease. UpToDate. Retrieved on 7/22/2013 from www.uptodate.com. (2013)

Parkinson's Disease Foundation: Statistics on Parkinson's. Retrieved 7/22/2013 from http://www.pdf.org/en/parkinson_statistics. (2013)

Fritsch T, K Smyth, M Wallendal, T Hyde, G Leo, D Geldmacher: Parkinson Disease: Research update and clinical management. Southern Medical Association 105(12), 650-656(2012)http://dx.doi.org/10.1097/SMJ.0b013e318273a60dPMid:23211499

Wright Willis A, B Evanoff, M Lian, S Criswell, B Racette: Geographic and ethnic variation in Parkinson Disease: A population-based study of US Medicare Beneficiaries.Neuroepidemiology,34,143151(2010)http://dx.doi.org/10.1159/000275491

PMid:20090375 PMCid:PMC2865395

Chinta S, C Lieu, M Demaria, R Laberge, J Campisi, J Anderson: Environmental stress, ageing, and glial cell senescence: A novel mechanistic link to Parkinson's Disease? Journal of Internal Medicine 273, 429-436 (2013)

MacPhee G, D Stewart: Parkinson's Disease. Reviews in Clinical Gerontology 11, 33-49 (2001)

Gazewood J, D Richards, K Clebak: Parkinson Disease: An update. American Family Physician 87(4), 267-273 (2013)

Brown T, P Rumsby, A Capleton, L Rushton, L Levy: Pesticides and Parkinson's Disease: Is there a link? Environmental Health Perspectives 14(2), 156-164 (2006)

Ceccatelli S: Mechanisms of neurotoxicity and implications for neurological disorders. Journal of Internal Medicine 273, 426-429 (2013)

http://dx.doi.org/10.1111/joim.12053 PMid:23600397

Jankovic J, H Hurtig, J Dashe: Etiology and pathogenesis of Parkinson Disease. UpToDate. Retrieved on 7/22/2013 from www.uptodate.com. (2013)

Postuma R, J Gagnon, J Montplaisir: Clinical prediction of Parkinson's Disease: Planning for the age of neuroprotection. Journal of Neurology (81)9, 1008-1013 (2009).

Hawkes C, K Del Tredici, H Braak: Review: Parkinson's Disease: A dual-hit hypothesis. Neuropathology and Applied Neurobiology 33, 599-614 (2007)

http://dx.doi.org/10.1111/j.1365-2990.2007.00874.x PMid:17961138

Savica R, B Grossardt, J Bower, J Ahlskog, W Rocca: Risk factors for Parkinson's Disease may differ in men and women: An exploratory study. Hormones and Behavior 63, 308-314(2013)http://dx.doi.org/10.1016/j.yhbeh.2012.05.013PMid:22687345

Chou K: Diagnosis of Parkinson Disease. UpToDate. Retrieved on 7/22/2013 from www.uptodate.com. (2013).

Shtilbans A, C Henchcliffe: Biomarkers in Parkinson's Disease: An update. Current Opinion of Neurology 25(4), 460-465 (2012)

http://dx.doi.org/10.1097/WCO.0b013e3283550c0d PMid:22772875

Fahn S. Parkinson's Disease: 10 Years of progress, 1997-2007. Movement Disorders 25(Suppl 1), S2-S14 (2010)

Frank C, G Pari, J Resisters: Approach to diagnosis of Parkinson Disease. Canadian Family Physician 52(7), 862-866 (2006)

Lew M. Overview of Parkinson's Disease. Pharmacotherapy 27(12 Pt 2), 155S-160S (2007)

Lim S, A Lang: The nonmotor symptoms of Parkinson's Disease-An overview. Movement Disorders 25(Suppl 1), S123-S130 (2010)

Jain S: Multi-organ autonomic dysfunction in Parkinson Disease. Parkinsonism and Related Disorders17,77-83(2011)http://dx.doi.org/10.1016/j.parkreldis.2010.08.022

PMid:20851033 PMCid:PMC3021587

Lohle M, A Storch, H Reichmann: Beyond tremor and rigidity: Non-motor features of Parkinson's Disease. Journal of Neural Transmission, 116, 1483-1492 (2009)

Aarsland D, M Beyer, M Kurz: Dementia in Parkinson's Disease. Current Opinion in Neurology21,676682(2088)http://dx.doi.org/10.1097/WCO.0b013e3283168df0PMid:18989112

Politis M, K Wu, S Molloy: Parkinson's Disease symptoms: The patient's perspective. Movement Disorders 25, 1646 (2010).

Opara J, W Brola, M Leonardi, B Blaszcyk: Quality of life in Parkinson's Disease. Journal of Medicine and Life 5(4), 375-381 (2012).

Yeo L, R Singh, M Gundeti, J Barua, J Masood: Urinary tract dysfunction in Parkinson's Disease: A review. International Urology Nephrology, 44, 415-424 (2012)http://dx.doi.org/10.1007/s11255-011-9969-yPMid:21553114

Brandabur M: Recognizing and treating nonmotor aspects of Parkinson's Disease. Annals of Long-Term Care 15(8), 331-35 (2007)

Tarsy D. Management of comorbid problems associated with Parkinson Disease upto- Date http://www.uptodate.com/contents/management-of-comorbid-problems-associated

Chaplin H, J Hazan, P Wilson: Self-management for people with long-term neurological conditions. British Journal of Community Nursing 17(6), 250-257 (2012)

Beitz J: Skin and wound issues in patients with Parkinson's Disease: An overview of common disorders. Ostomy Wound Management 59(6), 26-36 (2013).




DOI: http://dx.doi.org/10.24018/10.24018/iijmps.2018.v1i1.22

Refbacks

  • There are currently no refbacks.