A CRITICAL INFLUENCE OF SHAPES AND SIZES ON FLOW PROPERTIES OF DIFFERENT GRADES OF MICROCRYSTALLINE CELLULOSE

SHRUTIKA PATIL, SIBASIS BHATTACHARYA, MEENAKSHI MEENAKSHI, SUDHANSHU KUMAR PATEL

Abstract


Microcrystalline cellulose (MCC) has high demand and importance in pharmaceutical industry as fillers and binders. The physical properties like shape and size are one of the major contributor for the flow characteristics of bulk ingredients. The present study was designed to compare and quantify the influence of the size and shape on flow properties of 19 different grades of commercially available microcrystalline cellulose. The parameters evaluated include bulk density, tap density, compressibility index, Hausner's ratio, moisture content, average particle size, shape, angle of repose and sieve analysis as per USP specifications. The result obtained from these parameters showed different particle sizes ranging from 50-200µm and different shapes of particles like oval, spherical and one or both end curved rod shaped particles. The mixed variety size and shaped particles improved flow behavior, while small particle size and similar shaped particles of MCC showed poor flow ability.


Keywords


Physical stability, Physical characterization, Physico-chemical properties, Particle size, Excipients

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