A Review of Indazole Derivatives in Pharmacotherapy of Inflammation

Vishal Kumar, Kamini Gupta, Anup Kumar Sirbaiya, Md. Azizur Rahman

Abstract


Indazoles is an important class of heterocyclic compound. This review is aimed to collect different synthetic methods and the anti-inflammatory data of indazole derivatives. Literature surveys on scientific national and international journals, books as well as electronic resources were performed. Different synthetic methods and the anti-inflammatory data of indazole derivatives were compiled in the present review. From the literature survey, the best method for the synthesis of indazole derivatives was found to be compound 45. The indazole derivatives had shown various pharmacological activities such as antibacterial, anti-emetic, anticancer, MAO inhibitors, anti-convulsant, anti-protozoal, anti-asthmatic, HIV protease inhibitors, Rho kinase inhibitors, antihypertensive and other activities. Indazole shows different pharmacological activities as well as good anti-inflammatory activity due to their structural similarities with biomolecules like adenine and guanine, hence easily interact with biopolymer in living system.

Keywords


Indazole; Anti-inflammatory; Benzydamine; Diazotization; Hetrocycles

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DOI: http://dx.doi.org/10.24018/10.24018/iijmps.2018.v1i1.22

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