EFFECT OF NIGELLA SATIVA AQUEOUS SEED EXTRACT ON RATS DOSED WITH CADMIUM

Patience Waviche John, Madusolumuo M. A.

Abstract


Abstract

The effects of Nigella sativa aqueous seed extract on rats dosed with cadmium were investigated. Thirty six adult male rats were randomly divided into six groups (Groups A-F) of six rats each as follows: normal control, cadmium chloride (CdCl2) control, extract control, pretreatment, co-treatment and post-treatment. Cadmium chloride was orally administered for fourteen days at a single dose of 0.05mg/kg body weight while Nigella sativa seed extract was administered at single dose of 250mg/kg for fourteen days too.Changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein (TPT), total bilirubin (BIL), urea, creatinine (CRT),and lipid peroxidation in both the liver and kidney were profiled. The extract significantly lowered the increases in liver enzymes activities and the elevated levels of bilirubin, urea, creatinine and lipid peroxidation in treated animals (p<0.05). The most effective treatment observed was pretreatment followed by co-treatment with Nigella sativa seed extract. Nigella sativa seeds appeared safe, protective and preventive to damage resulting from exposure to cadmium.

 

Key word: Nigella sativa; seed extract; cadmium; toxicity; lipid peroxidation; modulation


Full Text:

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DOI: http://dx.doi.org/10.24018/10.24018/iijmps.2018.v1i1.22

DOI (24-26): http://dx.doi.org/10.24018/10.24018/iijmps.2018.v1i1.22

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