A REVIEW ON TRANSFEROSOMES AS ULTRA DEFORMABLE VESICULAR CARRIERS FOR TRANSDERMAL DRUG DELIVERY

Ravalika Veldurthi, A.Krishna Sailaja

Abstract


Transdermal drug delivery systems (TDDS) provide a number of potential advantages over conventional dosage forms such as injectables and oral delivery. However, the major drawback of TDDS is the permeability of the skin, it is permeable to small molecules, lipophilic drugs and highly impermeable to macromolecules and hydrophilic drugs. Stratum corneum (SC) is the main barrier and rate-limiting step for diffusion of drugs across the skin. Recent approaches in modulating vesicle compositions have been investigated to develop systems that are capable of carrying drugs and macromolecules to deeper tissues. These approaches have resulted in the design of two novel vesicular carriers, ethosomes and ultraflexible lipid-based elastic vesicles, transferosomes

Key word: Transdermal drug delivery, Transferosomes, Skin, Stratum corneum.


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DOI: http://dx.doi.org/10.24018/10.24018/iijmps.2018.v1i1.22

DOI (3-5): http://dx.doi.org/10.24018/10.24018/iijmps.2018.v1i1.22

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