AN OVERALL REVIEW ON TOPICAL PREPARATION-GEL

A.Krishna sailaja, R Supraja

Abstract


Topical application has many advantages over the conventional dosage forms. In general, they are deemed more effective less toxic than conventional formulations due to the bilayer composition and structure. In the formulation of topical dosage forms,attempts are being made to utilize drug carriers that ensure adequate localization or penetration of the drug within or through the skin in order to enhance the local and minimize the systemic effects, or to ensure adequate percutaneous absorption. Topical preparation avoids the GI-irritation, prevent the metabolism of drug in the liver and increase the bioavailability of the drug. Topical preparations give its action directly at the site of action. In this review a detailed discussion was made on the properties, classification, characterization, preparation and applications of gel.


Full Text:

17-20

References


REFERENCES

Alvarez-Soria M.A., Herrero-Beaumont G, Moreno-Rubio J.et al.: “ Long-term NSAID treatment directly deceases COX-2 and Mpges-1 production in the articular cartilage of patients with osteoatheritis,”ostroartherities and cartilage, 2008,16(12);1484-1493.

2) Li.L,Rossoni G, Sparatore A, Lee L.C. Del Soldato P and MooreP.K. “Anti-inflammoraty and gastrointestinal effects of a novel diclofenac derivative, “Free Radial Bioalogy and Medicine, 2007,42(5);706-719.

Cevc G, Gebauer D,Stiber J,Schatzlein A, Blume G.:Ultra flexible vesicles , transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin,Biochemica et Biophysica Acta,1998,1368;201-215.

Trommer H,Neubert RH:Overcoming the stratu corneum: the modulation skin penetration, skin pharmacology and physiology,2006,19:106-121.

Karande P,Mitragotri S:Enhancement of transdermal drug delivery via synergistic action of chemicals, Biochemica et Biophysica Actas,2009, 1788:2362-2373.

Williams AC,Barry BW:Penetration enhancers,Advanced Drug Delivery via Reviews 2004,5:603-618.

Barry BW: Novel mechanism and devices to enable successful transdermal drug delivery, European journal of pharmaceutical sciences,2001,14:101-114.

Devi R .S, Narayan S, Vani G, and Shymala Devi C.S.: “Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer”, Chemical-biological interactions,2007,167(1);71-83.

Vyas SP. Khar RK. Targeted and controlled Drug delivery. Novel carrier Systems. J CBS Publications 2002:331-87.

Panchagnula R, “Transdermal delivery of drugs”, Indian Journal Pharmacology, 1997, 29, 140-156.

Cevc G, Schatzlein A, Blume G. Transdermal drug carriers: Basic properties, optimization and transfer efficiency in case of epicutaneously applied peptides. J. Control. Rel.1995; 36:3-16.




DOI: http://dx.doi.org/10.24018/10.24018/iijmps.2018.v1i1.22

DOI (17-20): http://dx.doi.org/10.24018/10.24018/iijmps.2018.v1i1.22

Refbacks

  • There are currently no refbacks.