Debarshi Kar Mahapatra, Kanhaiya M Dadure, Ruchi S Shivhare


The unresolved hunger for the search of still better inhibitors has motivated us to move towards the next step where uracil, a component of the human body and an emerging anti-proliferative have been conjugated with an intention to improve the pharmacodynamics of the murrayanine hybrids. In the present research, uracil-containing murrayanine based (thio)-semicarbazide hybrids were rationally developed where all the 4 anti-tumor constituents (murrayanine, uracil, Schiff’s base, and (thio)-semicarbazide) were integrated and screened against breast cancer cell line MCF-7 against Sulforhodamine B (SRB) assay. The current research aimed to demonstrate noteworthy cytotoxic potential as compared with the previously reported murrayanine-thiosemicarbazide. The sophisticated analytical techniques aided in confirming the fabricated molecular structures. The derivative (3) expressed better activity than the compound (5) with IC50 values of 64.92 μM and 77.31 μM, respectively. The mechanism of action of the fabricated compounds was not at all known from this study and need to be explored comprehensively in successive studies. However, the incorporation of the uracil fragment in the derivative is not the sole approach to developing the better compound. Although, the present study will open new avenues of research in developing better inhibitors in the upcoming future by surely motivating the medicinal chemists.


Murrayanine; Uracil; Thiosemicarbazide; Semicarbazide; Schiff’s base; Anticancer; Breast cancer

Full Text:



Mahapatra DK, Bharti SK. Handbook of Research on Medicinal Chemistry. New Jersey: Apple Academic Press, 2017.

Kathane LL, Kuhite NG, Padhole CD, Amdare MD, Jogdand KR, Mahapatra DK. Anti-breast cancer perspective of a newly developed 2,4-disubstituted thiazole derivative. Int J Fund Appl Sci 2017;7(1):13-16.

Mahapatra DK, Bharti SK, Asati V. Anti-cancer Chalcones: Structural and molecular targets perspectives. Eur J Med Chem 2015;98:69-114.

Mahapatra DK, Bharti SK. Drug Design. New Delhi: Tara Publications Private Limited, 2016.

Shivhare RS, Mahapatra DK, Nair RR, Deshmukh SN. Schiff’s base derivatives of murrayanine demonstrated enhanced anti-oxidant activity than its parent moiety. Indian J Pharm Edu Res. 2016; 50(4): 9-15.

Mahapatra DK, Chhajed SS, Shivhare RS. Development of Murrayanine-Chalcone hybrids: An effort to combine two privilege scaffolds for enhancing hypoglycemic activity. Int J Pharm Chem Anal 2017;4(2):30-34.

Mahapatra DK, Das D, Shivhare RS, Borkar SS. Murrayanine-hydantoin and -thiohydantoin analogs as promising anti-convulsant agents: Synthesis, Characterization and Molecular Docking Studies. MOJ Bioorg Org Chem 2018;2(2):47-51.

Mahapatra DK, Dadure KM, Shivhare RS. Edema Reducing Potentials of Some Emerging Schiff’s bases of Murrayanine. MOJ Bioorg Org Chem 2018;2(4):172-175.

Mahapatra DK, Shivhare RS, Bharti SK. Novel Murrayanine based Pyrazole analogs as emerging anti-fungal candidates: Design, synthesis, characterization, and in vitro evaluation. Res Pharm 2017;1(1):1-5.

Mahapatra DK, Shivhare RS. Synthesizing an anti-oxidant principle 2-(((1-methoxy-9H-carbazol-3-yl)methylene)amino)isoindoline-1,3-dione from N-aminophthalimide and murrayanine. Inventi Med Chem 2017;2017(4):1-3.

Mahapatra DK, Shivhare RS, Joseph TM. Design and characterization of Murrayanine linked Isoxazole derivatives: Novel class of bacteriocidal agents. Int J Res Drugs Pharm Sci 2017;1(1):11-15.

Mahapatra DK, Shivhare RS, Kumar P. Murrayanine-chalcone transformed into novel pyrimidine compounds demonstrated promising anti-inflammatory activity. Asian J Pharm Res 2018;8(1):6-10.

Mahapatra DK, Shivhare RS, Asati V. Locomotor inhibitory activity of some Murrayanine-Chalcone based 2,3-dihydrobenzo[b][1,4]thiazepine derivatives: Exploring Anxiolytic potentials. Chron Pharm Sci 2018;2(1):462-468.

Mahapatra DK, Das D, Shivhare RS. Substituted thiazole linked murrayanine-Schiff’s base derivatives as potential anti-breast cancer candidates: Future EGFR Kinase inhibitors. Int J Pharm Sci Drug Res 2017;9(3):139-144.

Mahapatra DK, Shivhare RS, Dadure KM. Transforming Murrayanine-Chalcone into corresponding 3H-benzo[b][1,4]diazepine derivatives: Accessing the anti-anxiety effect by inhibition of locomotor activity. Acta Sci Pharm Sci 2018;2(5):40-44.

Mahapatra DK, Shivhare RS, Haldar AGM. Novel Schiff’s base containing Murrayanine–1,3,4-Thiadiazole Hybrids as potential anti-inflammatory agents. Asian J Chem Pharm Sci 2017;2(2):10-15.

Mahapatra DK, Shivhare RS, Gupta SD. Anxiolytic activity of some 2,3-dihydrobenzo[b][1,4]oxazepine derivatives synthesized from Murrayanine-Chalcone. Asian J Res Pharm Sci 2018;8(1):25-29.

Mahapatra DK, Shivhare RS. 3′,4′-Methylenedioxy Moiety Containing Murrayanine Based Chalcone as Emerging Anti-inflammatory Agent. J Modern Chem Chem Technol 2018;9(1):12-16.

Mahapatra DK, Shivhare RS, Ugale VG. Anti-inflammatory potentials of some novel Murrayanine containing 1,3,4-Oxadiazole derivatives. Asian J Pharm Technol 2018;8(1):47-51.

Mahapatra DK, Shivhare RS. Anti-microbial Perspective of a Chalcone, (E)-1-(1-methoxy-9H-carbazol-3-yl)-3-(4-(methylsulfonyl)phenyl)prop-2-en-1-one: Fabrication of a Hybrid by Unification of a Natural Product with a Synthetic Component. Int J Agri Life Sci 2018;4(2):236-240.

Mahapatra DK, Dadure KM, Shivhare RS. Exploring the Site-Specific Influence of Hydroxyl group in Ring-B of Murrayanine-Chalcone on Edema Reducing Potential. MOJ Drug Des Devel Ther 2018;2(4):191-194.

Chhajed SS, Upasani CD, Wadher SJ, Mahapatra DK. Medicinal Chemistry. Nashik: Career Publications Private Limited, 2017.

Mahapatra DK, Bharti SK. Medicinal Chemistry with Pharmaceutical Product Development. New Jersey: Apple Academic Press, 2018.

Mo WB, Su CH, Huang JY, Liu J, Chen ZF, Cheng KG. Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity. Chem Cent J 2016;10(1):69.

ElKalyoubi S, Fayed E. Synthesis and evaluation of antitumour activities of novel fused tri-and tetracyclic uracil derivatives. J Chem Res 2016;40(12):771-777.

Padole CD, Amdare MD, Jogdand KR, Kathane LL, Kuhite NG, Mahapatra DK. Discovery of 4-methyl-2-oxo-2H-chromen-7-yl-2-benzamidoacetate as Anti-proliferative Agent. Int J Ayur Pharm Chem 2018;8(1):62-68.


  • There are currently no refbacks.