ROLE OF FLAVONOIDS AS AN ANTI-INFLAMMATORY AGENT

Main Article Content

Poonam Poonam
Hem Raj Vashist
Ram Babu Sharma
Shivani Dorga

Abstract

Flavonoids are polyphenolic compounds that occur in plants having a variety of biological effects both in vitro and in vivo. They have been found to have antimicrobial, antiviral, anti-ulcerogenic, cytotoxic, antineoplastic, mutagenic, antioxidant, antihepatotoxic, antihypertensive, hypolipidemic, antiplatelet and anti-inflammatory activities. Flavonoids also have biochemical effects, which inhibit a number of enzymes such as aldose reductase, xanthine oxidase, phosphodiesterase, Ca+2-ATPase, lipoxygenase, cyclooxygenase, etc. They also have a regulatory role on different hormones like estrogens, androgens and thyroid hormone. They have been found to have anti-inflammatory activity in both proliferative and exudative phases of inflammation. Several mechanisms of action have been proposed toexplain anti-inflammatory action of flavonoids. The aim of the present review is to give an overview of the mechanism of action of potential anti-inflammatory flavonoids. This review focuses on thephysicochemical properties, dietary sources, absorption,bioavailability and metabolism of quercetin, especially main effects of quercetin oninflammationand immune function. According to the results obtained both in vitro and in vivo, good inflammation have been opened for quercetin. Nevertheless, further studies are needed to better char inflammation mechanisms of action underlying the beneficial effects of quercetin on inflammation and immunity. 

 

 

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How to Cite
Poonam, P., Vashist, H. R., Sharma, R. B., & Dorga, S. (2019). ROLE OF FLAVONOIDS AS AN ANTI-INFLAMMATORY AGENT. Innovat International Journal Of Medical & Pharmaceutical Sciences, 4(3). https://doi.org/10.24018/10.24018/iijmps.2018.v1i1.22
Section
Review Article(s)

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