Main Article Content

Poonam Poonam
Hem Raj Vashist
Ram Babu Sharma
Shivani Dorga


Flavonoids are polyphenolic compounds that occur in plants having a variety of biological effects both in vitro and in vivo. They have been found to have antimicrobial, antiviral, anti-ulcerogenic, cytotoxic, antineoplastic, mutagenic, antioxidant, antihepatotoxic, antihypertensive, hypolipidemic, antiplatelet and anti-inflammatory activities. Flavonoids also have biochemical effects, which inhibit a number of enzymes such as aldose reductase, xanthine oxidase, phosphodiesterase, Ca+2-ATPase, lipoxygenase, cyclooxygenase, etc. They also have a regulatory role on different hormones like estrogens, androgens and thyroid hormone. They have been found to have anti-inflammatory activity in both proliferative and exudative phases of inflammation. Several mechanisms of action have been proposed toexplain anti-inflammatory action of flavonoids. The aim of the present review is to give an overview of the mechanism of action of potential anti-inflammatory flavonoids. This review focuses on thephysicochemical properties, dietary sources, absorption,bioavailability and metabolism of quercetin, especially main effects of quercetin oninflammationand immune function. According to the results obtained both in vitro and in vivo, good inflammation have been opened for quercetin. Nevertheless, further studies are needed to better char inflammation mechanisms of action underlying the beneficial effects of quercetin on inflammation and immunity. 




Download data is not yet available.

Article Details

How to Cite
Poonam, P., Vashist, H. R., Sharma, R. B., & Dorga, S. (2019). ROLE OF FLAVONOIDS AS AN ANTI-INFLAMMATORY AGENT. Innovat International Journal Of Medical & Pharmaceutical Sciences, 4(3).
Review Article(s)


. Mohammed Mona S., Wadah J. A. Osman*, Elrashied A. E. Geralnabi, Zuheiroswan, BashierOswan, Hassan S, Khalid, Magdi A. Mohammed. The journal of pharmacology 2014; 3(4) : 275-285.

. Rodrigo Guabiraba, Ana Lucia Campanha-Rodrigues, Adriano L.S. Souza, Helton C. Santiago, Claire Lugnier, Jacqueline Alvarez-Leite, Virginia S. Lemos, Mauro M. Teixeira. The flavonoid dioclein reduces the production of proinflammatory mediators in vitro by inhibiting PDE4 activity and scavenging reactive oxygen species. European Journal of Pharmacology; 2010: 633: 85–92.

. O.A. Fawole, A.R. Ndhlala, S.O. Amoo, J.F. Finnie, J. Van Staden. Anti-inflammatory and phytochemical properties of twelve medicinal plants used for treating gastro-intestinal ailments in South Africa. Ethnopharmacology ;2009, 123: 237–243.

.A. N. Panchi’1,2, A. D. Diwan 2*and S. R. Chandra’, Journal of Nutritional Science (2016), vol. 5, e47, page 1 of 15.

.Burak M &Imen Y (1999) Flavonoids and their antioxidant properties. TurkiyeKlin Tip BilDerg 19, 296–304.

.Ovando C, Hernandez D, Hernandez E, et al. (2009) Chemical studies of anthocyanins: a review. Food Chem 113, 859–871.

.Hamer M & Steptoe A (2006) Influence of specific nutrients on progression of atherosclerosis, vascular function, haemostasis and inflammation in coronary heart disease patients: a systematic review. Br J Nutr 95, 849–859.

.Serafini M, Villano D, Spera G et al. (2006) Redox molecules and cancer prevention: the importance of understanding the role of the antioxidant network. Nutr Cancer 56,232–240.

.Iwashina T (2013) Flavonoid properties of five families newly incorporated into the order Caryophyllales (Review). Bull NatlMus Nat Sci 39, 25–51.

.Matthies A, Clavel T, Gütschow M, et al. (2008) Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine. ApplEnvrionMicrobiol 74, 4847–4852

.Linuma M, Tanaka T, Hamada K, et al. (1987) Revised structure of neoflavone in Coutareahexandra. Phytochemistry 26, 3096–3097.

.Nishimura S, Taki M, Takaishi S, et al. (2000) Structures of 4-arylcoumarin (neoflavone) dimers isolated from Pistaciachinensis BUNGE and their estrogen-like activity. Chem Pharm Bull (Tokyo) 48, 505–508.

.Garazd M, Garazd Y &Khilya V (2003) Neoflavones. 1. Natural distribution and spectral and biological properties. Chem Nat Comp39, 54–12.

.Davis, J.M.; Murphy, E.A.; Carmichael, M.D. Effects of the dietary flavonoid quercetin upon performance and health. Curr.Sports Med. Rep. 2009, 8, 206–213. [CrossRef] [PubMed].

.Aguirre, L.; Arias, N.; Macarulla, M.T.; Gracia, A.; Portillo, M.P. Beneficial effects of quercetin on obesity and diabetes. Open Nutraceuticals J. 2011, 4, 189–198.

.Smith, C.; Lombard, K.A.; Peffley, E.B.; Liu, W. Genetic analysis of quercetin in onion (Allium cepa L.) Lady Raider. Tex. J. Agric. Natl. Resour. 2003, 16, 24–28.

. Mitchell, A.E.; Hong, Y.J.; Koh, E.; Barrett, D.M.; Bryant, D.E.; Denison, R.F.; Kaffka, S. Ten-year comparison of the influence of organic and conventional crop management practices on the content of flavonoids in tomatoes. J. Agric. Food Chem. 2007, 55, 6154–6159. [CrossRef] [PubMed].

.Petrus, K.; Schwartz, H.; Sontag, G. Analysis of flavonoids in honey by HPLC coupled with coulometric electrode array detection and electrospray ionization mass spectrometry. Anal.Bioanal. Chem. 2011, 400, 2555–2563. [CrossRef] [PubMed).

.A Shamsizadeh, A Moghaddamahmadi, in Nutrition and Life Style in Neurological Autoimmune Disease, 2017.

.Sai-ching Jim Yeung, in Advance in Molecular and cellular Endocrinology, 2006.

.M Shields, in Pharmacognosy, 2017.