ACUTE TOXICITY STUDY AQUEOUS EXTRACTS OF ALOE SINKATANA LEAVES IN WISTAR ALBINO RATS
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Abstract
This study was carried out on Wistar albino rats to evaluate the toxicity of Aloe sinkatana plant which treats a variety of ailments, including skin diseases, constipation, fever and inflamed colon. The present study showed the effect of aqueous extract of A. sinkatana at three different doses 175, 300 and 500 mg\kg\day administered orally for 2weeks. The characteristic toxicity of the plant extract was evident on kidney, liver and intestine. This toxic effect is subsequent to changes in the activity of aspartate transaminase (AST) alanine transaminase (ALT), and alkaline phosphatase (ALP) enzymes and the concentration of Globulin in serum and caused normocytic hypochromic anemia.
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