A REVIEW OF INDAZOLE DERIVATIVES IN PHARMACOTHERAPY OF INFLAMMATION

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Published: Oct 8, 2021
Keywords:
Indazole Anti-inflammatory Benzydamine Diazotization Hetrocycles.

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VISHAL KUMAR
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
KAMINI GUPTA
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
ANUP KUMAR SIRBAIYA
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
MD AZIZUR RAHMAN
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh

Abstract

ndazole is an important class of heterocyclic compound. This review is aimed to collect different synthetic methods and the anti-inflammatory data of indazole derivatives. Literature surveys on scientific national and international journals, books as well as electronic resources were performed. Different synthetic methods and the anti-inflammatory data of indazole derivatives were compiled in the present review. From the literature survey, the best method for the synthesis of indazole derivatives was found to be compound 45. The indazole derivatives had shown various pharmacological activities such as antibacterial, anti-emetic, anticancer, MAO inhibitors, anti-convulsant, anti-protozoal, anti-asthmatic, HIV protease inhibitors, Rho kinase inhibitors, antihypertensive and other activities. Indazole shows different pharmacological activities as well as good anti-inflammatory activity due to their structural similarities with biomolecules like adenine and guanine, hence easily interact with biopolymer in living system.

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How to Cite
KUMAR, V., GUPTA, K., KUMAR SIRBAIYA, A., & AZIZUR RAHMAN, M. (2021). A REVIEW OF INDAZOLE DERIVATIVES IN PHARMACOTHERAPY OF INFLAMMATION. Innovat International Journal Of Medical & Pharmaceutical Sciences, 6(5), 7–12. Retrieved from https://innovatpublisher.com/index.php/iijmps/article/view/157
Issue
Vol 6 Issue 5 2021
Section
Review Article(s)

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