ETHANOPHARMACOLOGICAL REVIEW OF HERBAL DRUGS AGAINST ANTI-TUBERCULAR DRUGS INDUCED HEPATOTOXICITY: CURRENT PERSPECTIVES

Abstract

Throughout the world, liver diseases have developed as a major problem in huge population proportions. As it is a known fact that liver has the competence for the noxious substances to detoxicate them, since then liver damage is very much frequent. The interruption of the TB chemotherapy occurred due to the development of the drug induced hepatotoxicity (DIH), the most widespread reason for it. Isoniazid (I) and Rifampicin (R) are the drugs included in the presently regimen of TB chemotherapy, which leads to the potentially serious adverse effect of DIH. It is considerably found that medicinal plants are a major source as Hepatoprotective drugs. In perspective on this reality, numerous mono and poly-natural arrangements are utilized in different liver disorder. As per one estimate, clinically over 700 natural origin medicaments in which around 100 herbal plants are being used. A cure which is having useful outcome on the liver is called to be as hepatoprotective medication. In actuality, cures which are having toxic impact on liver are better archived as hepatotoxic medications. Many scientific investigations have stated that herbal plants are having authentic usefulness in liver disease treatment. This review compiled imperative information regarding some plants and their extract which showed protective effect in antitubercular DIH. The various herbal plants studied herein for their liver protective action against liver toxicity actuated by different antitubercular drugs.