GASTRO RETENTIVE FLOATING MATRIX FORMULATION OF LANSOPROZOLE BY USING VARIOUS HYDROPHILIC POLYMERS.

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NM Vageesh
Ramya Sri Sura
D Rafian
U Govindamma

Abstract

Objective: In the present research work the gastro retentive floating matrix formulation of Lansoprozole by using various hydrophilic polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized.

Methods: Then the formulation was developed by using different concentrations of polymers of various grades of HPMC. The formulation blend was subjected to various pre-formulation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties.

Results: Among all the formulations the formulations prepared by using HPMC K4M were unable to produce desired drug release; they were unable to retard drug release up to 12 hours. The formulations prepared with HPMC K100M were also retarded the drug release for more than 12 hours. Hence they were not considered. The formulations prepared with HPMC K 15 M retarded the drug release up to 12 hours in the concentration of 60 mg (F6).

Conclusion: The optimized formulation dissolution data was subjected to release kinetics; from the release kinetics data it was evident that the formulation followed Higuchi mechanism of drug release.

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How to Cite
Vageesh, N., Sura, R. S., Rafian, D., & Govindamma, U. (2017). GASTRO RETENTIVE FLOATING MATRIX FORMULATION OF LANSOPROZOLE BY USING VARIOUS HYDROPHILIC POLYMERS. Innovat International Journal Of Medical & Pharmaceutical Sciences, 2(4). https://doi.org/10.24018/10.24018/iijmps.2018.v1i1.22
Section
Original Article(s)
Author Biography

NM Vageesh, KAKATIYA UNIVERSITY WARANGAL

Dept.of Pharmaceutical analysis

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