Main Article Content

K Mediga Kiran kumar
AT Thirupathi
K Naga raju
B Deepika
K Rajeswar dutt


Gymnosperia emarginata (Willd.) grow in moderately fertile, moist but well†drained soil in full sun with midday shade. This study investigated the antiepileptic of the ethanolic leaf extract of the plant. Three widely used animal models of epilepsy namely the pentylenetetrazole, picrotoxin and maximal electroshock-induced seizure tests were used to evaluate the anticonvulsant effects of the extract. In the pentylenetetrazole-induced seizures, ethanolic extracts   of Gymnosperia emarginata  (50,100 and 200 mg/kg p.o) caused marked and dose-dependent delay of the onset of myoclonic jerks and decreased the duration of tonic-clonic convulsions. The extract delayed the onset of tonic convulsions and decreased the frequency of convulsions induced by pentylenetetrazole. Onset of tonic convulsions induced by picrotoxin was also significantly delayed by Gymnosperia emarginata and the frequency and duration of convulsions significantly reduced. The onset of picrotoxin-induced myoclonic jerks was delayed by the extract. Again, the extract showed marked anticonvulsant activity by significantly reducing the duration  of maximal electroshock-induced tonic hind limb extension. Administration of Gymnosperia emarginata  (50,100 and 200 mg/kg p.o) in rats caused significant anxiolytic effects similar to that of diazepam (20 mg/kg i.p) and opposite to that of pentylenetetrazole (3-30 mg/kg i.p) increased the frequency and duration of unprotected stretch-attend postures as well as unprotected head dips.

In conclusion, the results indicate that the leaves of Gymnosperia emarginata  produces anticonvulsant effect through central mechanisms which support the traditional use of the plant to treat epileptic fits


Download data is not yet available.

Article Details

How to Cite
Kiran kumar, K. M., Thirupathi, A., Naga raju, K., Deepika, B., Rao, K., & Rajeswar dutt, K. (2017). PHYTOCHEMICAL SCREENIONG AND PHARMACOLOGICAL EVALUATION OF ANTI-EPILETIC ACTIVITY OF ETHANOLIC EXTRACT OF GYMNOSPORIA EMARGINATA ON ELECTRIC SHOCK AND PTZ-INDUCED CONVULSIONS IN RATS. Innovat International Journal Of Medical & Pharmaceutical Sciences, 2(7).
Original Article(s)


Epilepsy Foundation. (2012a). About epilepsy. Retrieved May 8, 2012, a from

NIH. (2012). Epilepsy. Retrieved May 11, 2012, from

Thurman, D. J., Beghi, E., Begley, C. E., Berg, A. T., Buchhalter, J. R., Ding, D., Hesdorffer, D. C., et al. (2011). Standards for epidemiologic studies and surveillance of epilepsy. Epilepsia, 52 Suppl 7(1), 2-26.

Kotagal, P. (2011). Neurostimulation: vagus nerve stimulation and beyond. Seminars in pediatric neurology, 18(3), 186-194.

Moshi, M. J., Kagashe, G. a B., & Mbwambo, Z. H. (2005). Plants used to treat epilepsy by Tanzanian traditional healers. Journal of ethnopharmacology, 97(2), 327-336.

Epilepsy Foundation. (2012b). Health risks. Retrieved May 8, 2012, b from

Surges, R., & Sander, J. W. (2012). Sudden unexpected death in epilepsy. Current Opinion in Neurology, 25(2), 201-207.

NINDS. (2004). Seizures and Epilepsy: hope through research. Retrieved May 11, 2012, from

Berg, A. T., Berkovic, S. F., Brodie, M. J., Buchhalter, J., Cross, J. H., van Emde Boas, W., Engel, J., et al. (2010). Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia, 51(4), 676-85.

Ceulemans, B. (2011). Overall management of patients with Dravet syndrome. Developmental medicine and child neurology, 53 Suppl 2, 19-23.

Vanstraten, A. F., & Ng, Y.-T. (2012). Update on the management of lennox-gastaut syndrome. Pediatric neurology, 47(3), 153-61.

Mastrangelo, M., Mariani, R., & Menichella, A. (2010). Eponym : Rasmussen syndrome. European journal of pediatrics, 169(8), 919-24.

Kwan, P, Sills, GJ, Brodie, MJ (2001) The mechanisms of action of commonly used antiepileptic drugs. Pharmacol Ther 90(1): 21-34.

Deckers, CL, Genton, P, Sills, GJ, Schmidt, D (2003) Current limitations of antiepileptic drug therapy: a conference review. Epilepsy Res 53(1-2): 1-17.

Ochoa, J. G., Riche, W., Rossaro, E. A., Talavera, F., Cavazos, J. E., & Benadis, S. (2012). Antiepileptic Drugs. Retrieved March 28, 2012, from

Emory. (1999). No Title. Retrieved May 23, 2012, from

Gécz, J. (2010). Glutamate receptors and learning and memory. Nature genetics, 42(11), 925-926.

Schmidt, D. (2009). Drug treatment of epilepsy: options and limitations. Epilepsy & Behavior, 15(1), 56-65.

Most read articles by the same author(s)