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The purpose of this study is to formulation and in vitro evaluation of floating microbeads of Bosentan using ionic gelation method. The floating microbeads were taken for micromeritic properties such as bulk density, tapped density, carrs index, hausners ratio, angle of repose which were found to be within limits. From the dissolution data it was evident that, formulations prepared with Sodium alginate and HPMC K 100 were revealed that formulations may not contain even 90% of drug. Hence those formulations were not considered. Formulations prepared with Sodium alginate was shown those contain more than 90% of drug. F4 formulation was retarding the maximum drug release up to 12 hrs. Hence It was considered as optimised formulation. Optimised formulation kept for kinetic study. It was followed Zero order release kinetics.
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