FORMULATION DEVLOPMENT AND CHARACTERIZATION OF FLOATING MICROSPHERES CONTAINING CINNARIZINE
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Abstract
Gastroretentive dosage forms have potential for  use as controlled- release drug delivery systems. The aim of the present study is formulation and characterization of floating microspheres using Cinnarizine as a model drug for the management of Emesis. Floating microspheres were prepared by solvent evaporation technique using Sodium Alginate,  Guar gum and Eudragit S100 as release retarding polymers. The floating microspheres were evaluated for percentage yield (%), Mean particle size, drug content, drug entrapment efficiency, In vitro Buoyancy and in vitro drug release studies. Compatibility studies were performed by fourier transform infrared (FTIR) technique. The prepared microspheres showed prolonged drug release of 12 h. The optimized formulation (F11) showed better drug release 99.61% for 12 hours. It was concluded that developed floating microspheres of Cinnarizine offers a suitable and practical approach for prolonged release of drug over an extended period of time and thus oral bioavailability, efficacy and patient compliance is improved.
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