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GastroretentiveÂ dosageÂ formsÂ haveÂ potentialÂ for Â useÂ asÂ controlled-Â release drugÂ delivery systems. TheÂ aimÂ ofÂ theÂ presentÂ studyÂ isÂ formulationÂ andÂ characterizationÂ ofÂ floatingÂ microspheresÂ using Cinnarizine as a model drug for the management of Emesis. Floating microspheres were prepared by solvent evaporation technique using Sodium Alginate, Â Guar gum and Eudragit S100 asÂ releaseÂ retardingÂ polymers.Â TheÂ floatingÂ microspheresÂ wereÂ evaluatedÂ forÂ percentageÂ yieldÂ (%), Mean particle size, drug content, drug entrapment efficiency, In vitro Buoyancy and in vitro drug release studies. Compatibility studiesÂ wereÂ performedÂ byÂ fourierÂ transformÂ infraredÂ (FTIR)Â technique.Â TheÂ preparedÂ microspheres showed prolonged drug release of 12 h. The optimizedÂ formulationÂ (F11) showed better drug release 99.61% for 12 hours. It was concluded that developed floating microspheres of Cinnarizine offers a suitable and practical approachÂ forÂ prolongedÂ releaseÂ ofÂ drugÂ overÂ anÂ extendedÂ periodÂ ofÂ timeÂ andÂ thusÂ oralÂ bioavailability, efficacy and patient compliance is improved.
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