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Rizatriptan Benzoate is a newer preferantionalCOX-1 inhibitor, has been used to relieve the symptoms of arthritis, primary dysmenorrhea, fever and as an analgesic, especially where there is an inflammatory component. The present work aimed at preparing oral fast quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Oral Disinetgrating Film of Rizatriptan Benzoate were prepared using HPMC ( E5, E15) and pullan gum polymers as film forming agents and PEG 400 as plasticizer by solvent casting method. FTIR showed that there is no interaction between drug and excipients. Dissolution of prepared Oral Disinetgrating Film of Rizatriptan Benzoate was performed using USP type II apparatus in pH 6.8 phosphate buffer medium at 50 rpm with temperature being maintained at 37 0.5ÂºC. The films prepared were evaluated for various parameters like thickness, percent elongation, drug content uniformity, weight variation, disintegration time, folding endurance and in vitro drug release and were showed satisfactory results. In conclusion, development of fast dissolving oral films using pullan gum polymer gives rapid drug delivery and rapid onset of action.F8 Forulation was found to be as optimized formulation.
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