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Surendra Naik
Hemanth Hemanth
N.M. Vageesh
K Basavaraju


Rizatriptan Benzoate is a newer preferantionalCOX-1 inhibitor, has been used to relieve the symptoms of arthritis, primary dysmenorrhea, fever and as an analgesic, especially where there is an inflammatory component. The present work aimed at preparing oral fast quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Oral Disinetgrating Film of Rizatriptan Benzoate were prepared using HPMC ( E5, E15) and pullan gum polymers as film forming agents and PEG 400 as plasticizer by solvent casting method. FTIR showed that there is no interaction between drug and excipients. Dissolution of prepared Oral Disinetgrating Film of Rizatriptan Benzoate was performed using USP type II apparatus in pH 6.8 phosphate buffer medium at 50 rpm with temperature being maintained at 37 0.5ºC. The films prepared were evaluated for various parameters like thickness, percent elongation, drug content uniformity, weight variation, disintegration time, folding endurance and in vitro drug release and were showed satisfactory results. In conclusion, development of fast dissolving oral films using pullan gum polymer gives rapid drug delivery and rapid onset of action.F8 Forulation was found to be as optimized formulation.


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Naik, S., Hemanth, H., Vageesh, N., & Basavaraju, K. (2018). FORMULATION AND IN VITRO EVALUATION OF RIZATRIPTAN BENZOATE ORAL DISINETGRATING FILM. Innovat International Journal Of Medical & Pharmaceutical Sciences, 3(1).
Original Article(s)


Aditya D, Nagarsenkar M Formulation and evaluation of Fast dissolving Film for delivery of Triclosan to the oral cavity. AAPS Pharma ScienceTechnology.2008; 9, 2:10

Arya A, Chandra A. Sharma V, Pathak K. Fast dissolving oral films: An innovative drug delivery system and dosage form. International Journal Chemical Technical Res 2010; 2: 576-583.

Anand V, Kataria M, Kukkar V, Saharan V, Choudhury PK. The latest trends in the taste assessment of pharmaceuticals. Drug Discovery Today 2007; 12: 257-265.

Arya A, Chandra A, Sharma V, Pathak K, Fast dissolving oral films: An Innovative Drug Delivery system and Dosage form. Int. J. Chem. Tech. Res. 2010, 2: 576-583.

Banker GS. Film coating theory and practice. Journal Pharma Science 1966; 55: 81†89.

Barnhart SD. Thin film oral dosage forms in Modified release. Drug delivery Techology 2007; 1: 34-35.

Barnhart S, Rathborne M, Hadgraft J, Roberts M, Lane M. Thin film oral dosage forms in Modified release drug delivery technology. 2nd ed., Drugs and the Pharmaceutical Science; 209-216.

BasaniGavaskar, SubashVijaya Kumar, Guru Sharan, Y.MadhusudhanRao, Overview on Fast Dissolving Films, International Journal of Pharmacy and Pharmaceutical Sciences, 2010, 2 (3): 29-33.

Bess WS, Kulkarni N, Ambike SH, Ramsay MP, Fast dissolving Orally Consumable Solid Film Containing a Taste Masking Agent and Pharmaceutically Active Agent at different weight ratio, 2006 Jun 27.

BhupinderBhyan, SaritaJangra, MandeepKaur, Harmanpreet Singh, Orally Fast Dissolving Films: Innovations in Formulation and Technology, International Journal of Pharmaceutical Sciences Review and Research, 2011, 9(2): 50-56.

Borsadia BB, Osborne JA. Quick dissolving films: A novel approach to drug delivery. Drug delivery Technology - Article index.

Brown D, Orally disintegrating tablets: Taste over speed. Drug Tech, 2001, 58-61.

Chang RK, Guo X, Burnside BA, Couch RA. Fast dissolving tablets. Pharma Tech 2000; 24(6): 52-58.

Chapdelaine AH, Zyck DJ, Dzija MR. Edible film formulations containing maltodextrin. US Patent. 2004.

Coppens KA, Hall MJ, Mitchell SA. Hypromellose, Ethyl cellulose and Polyethylene oxide used in hot melt extrusion. Pharmaceutical Technology 2005; 3: 1-6.

Corniello C. Quick dissolving strips: from concept to commercialization. Drug Delivery Technology 2006; 6: 68 â€71.

Cilurzo F, Minghetti P, Como A, Montanari L, Feasibility study of Fast Dissolving Film Containing Piroxicam. AAPS Pharma Science Technology 2005; 7:52.

Cilurzo F, Cupone IE, Minghetti P, Buratti S, Montanari L:Maltodextrin Fast dissolving Film Containing Nicotin: a feasibility study. AAPS PharmaScienceTechnology 2006; 11:2009-002039.

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