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G Swathi
N.M. Vageesh
Dr.C. Kistayya
Syed Javeed


In the present research work pulsatile drug delivery system of Theophylline tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by using various concentrations of super disintegrates , the formulated core tablets were coated with the polymers by using compression coating technology. All the  core  and  press  coated  tablet  formulations  were  subjected  to  various physical and chemical evaluation tests for core and press coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopoeial limits.  In vitro release of Theophylline of core tablet formulations F1-F3, F3 showed faster drug release after 15 mins. Faster drug release can be correlated with the high disintegration and friability observed in this study. The formulations C1, C2, and C3 showed maximum drug release at 4th hour. Time  dependent pulsatile drug delivery system has been achieved from tablet of formulation C6 and C8 with 102.79% and 100.21% drug release which meets demand of chronotherapeautic drug delivery. The formulations containing HPMC K15M and Ethylecellulose in 300 mg and 200 mg respectively were found to be optimum as enteric coating polymers. 


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Swathi, G., Vageesh, N., Kistayya, D., & Javeed, S. (2018). PREPARATION AND IN VITRO CHARACTERISATION OF PULSATILE DRUG DELIVERY SYSTEM OF THEOPHYLLINE. Innovat International Journal Of Medical & Pharmaceutical Sciences, 3(1).
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