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pavani s
Goutham P


Objective:Atenolol is β1-selective adrenergic blocking agent and widely used in the treatment of hypertension and angina pectoris. It has a bioavailability of 40-50%. The main objective of the study was to formulate taste masked oral disintegrating films of Atenolol to achieve a better dissolution rate by improving the bioavailability of the drug and providing quick onset of action there by enhancing patient compliance.

Method:Oral disintegrating films prepared by solvent casting method using film forming polymer HPMC E15 in different ratios.

Results: The prepared films were evaluated for the drug content, weight variation, film thickness, disintegration time and in vitro dissolution studies and taste mask studies on healthy human volunteers.

Conclusion:Among all, the formulation F3 containing HPMC E15 (drug: polymer of 1:2) was found to be best formulation which releases 99.89% of the drug within 20 min and disintegration time is 15.3 sec.

 Key word: Angina, HPMC-E15, Hypertension, taste masking,



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s, pavani, & P, G. (2017). FORMULATION DEVELOPMENT AND EVALUATION OF TASTE MASKED ORAL DISINTEGRATING FILMS OF ATENOLOL. Innovat International Journal Of Medical & Pharmaceutical Sciences, 2(2).


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